Analytical & Biological Mass Spectrometry Facility (About)

At the Analytical & Biological Mass Spectrometry Facility (ABMS), we have state-of-the-art equipment and unparalleled expertise for the analysis of a variety of biological and small molecules. One of our specializations includes protein-analysis encompassing: protein identification, protein and peptide sequence confirmation, intact protein molecular weight determination, complex protein sample analysis, and protein/antibody-drug interactions. In addition to proteomics, the ABMS team has developed an in-house metabolomics library (currently containing >700 compounds) to support metabolomic and lipidomics analysis, enabling the interrogation of the underlying metabolomic and lipidomics profiles. Through this proteomics, metabolomics, and lipidomics analysis, a greater in-depth and multi-omics profiling is achieved.

We can also identify a range of post-translational modifications (PTMs), determining their presence or absence, as well as quantitating the PTMs.

Our services are designed to assist you to answer your quantitative/qualitative proteomics and small molecule questions as well. The services include workflows for label free, chemical labeling (iTRAQ/TMT) and metabolic labeling (SILAC).

For chemists who would like to synthesize a molecule, we monitor the reaction step-by-step, calculate the percentage of product, test for its purity, and characterize the molecule with high resolution and high mass accuracy (typically better than 500 ppb [0.5 ppm] mass accuracy).

Whether you are interested in molecular weight and chemical composition determinations, structure elucidations and compound identification analysis or confirmation and accurate mass measurements of synthetic products, measurement of polymers, nucleic acids (DNA/RNA), peptides, proteins, natural products, and assistance with determination of unknowns. Or characterization of biological proteins, we look forward to supporting your research needs.

The Core is located in room 124J in the BIO5 Keating Bioresearch Building on the North Campus.

Email us with inquiries today at MassSpec@email.arizona.edu.